TYPO3's cache frontend (VariableFrontend) and persistent key-value store (Registry) deserialized PHP payloads without integrity validation or class restrictions. An attacker with write access to the underlying storage backend (cache store or sys_registry database table) could inject a crafted serialized payload to trigger PHP Object Injection, potentially exploiting a gadget chain to achieve Remote Code Execution or other high-impact effects. Exploiting this vulnerability requires direct local write access to the storage, such as the SQL database or file system. This issue affects TYPO3 CMS versions before 10.4.57, 11.0.0-11.5.51, 12.0.0-12.4.46, 13.0.0-13.4.31 and 14.0.0-14.3.3.